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Therapeutic applications Given the dependence of cancer cells on glutamine metabolism, targeted therapies have been developed against glutamine metabolism, from glutamine uptake to glutamine-catalysed enzymes

(Thieme, Stuttgart, 2017)

Biol Trace Element Res 160(1):116122

Furuta et al., 1997a)

Although iron chelation therapy was initially designed to alleviate the toxic effects of excess iron occurring in iron-overload diseases, the novel toxicological properties of some iron chelator complexes have radically shifted their intended applications toward cancer chemotherapy 7,8,9